Pseudo-Peptides Derived from Isomannide as Potential Inhibitors of Serine Proteases

Author(s)

Estela M.F. Muri, Universidade do Brasil
Marlito Gomes Jr., Universidade do Brasil
Magaly Girão Albuquerque, Universidade do Brasil
Elaine F. F. da Cunha, Universidade do Brasil
Ricardo Bicca de Alencastro, Universidade do Brasil
John S. Williamson, University of DaytonFollow
Octavio A.C. Antunes, Universidade do Brasil

Document Type

Article

Publication Date

6-2005

Publication Source

Amino Acids

Abstract

Hepatitis C, dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.

Inclusive pages

413–419

ISBN/ISSN

0939-4451

Comments

Permission documentation is on file.

Copyright

Copyright © 2005, Springer-Verlag/Wien

Publisher

Springer

Volume

28

Issue

4

Peer Reviewed

yes

eCommons Citation

Muri, Estela M.F.; Gomes, Marlito Jr.; Albuquerque, Magaly Girão; da Cunha, Elaine F. F.; de Alencastro, Ricardo Bicca; Williamson, John S.; and Antunes, Octavio A.C., "Pseudo-Peptides Derived from Isomannide as Potential Inhibitors of Serine Proteases" (2005). Office for Research Publications and Presentations. 1.
https://ecommons.udayton.edu/ofr_pub/1