Microbial Transformation of Artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger

Author(s)

Igor A. Parshikov, University of Mississippi
Bruhaspathy Miriyala, University of Mississippi
K. M. Muraleedharan, University of Mississippi
Mitchell A. Avery, University of Mississippi
John S. Williamson, University of DaytonFollow

Document Type

Article

Publication Date

5-2006

Publication Source

Journal of Industrial Microbiology and Biotechnology

Abstract

Transformation of the anti-malarial drug artemisinin by the fungi Eurotium amstelodami and Aspergillus niger were investigated. Cultures were grown in sucrose/malt broth with artemisinin for 14 days and extracted with ethyl acetate. Extracts were characterized by liquid chromatography. Two metabolites from each fungal extract were isolated and identified using mass spectrometry and nuclear magnetic resonance. 5β-hydroxyartemisinin and 7β-hydroxyartemisinin were isolated in 63 and 32% yields, respectively, from the extract of E. amstelodami, and 80 and 19%, respectively, from the extract of A. niger.

Inclusive pages

349–352

ISBN/ISSN

1367-5435

Comments

Permission documentation is on file.

Copyright

Copyright © 2006, Society for Industrial Microbiology

Publisher

Springer

Volume

33

Issue

5

Peer Reviewed

yes

eCommons Citation

Parshikov, Igor A.; Miriyala, Bruhaspathy; Muraleedharan, K. M.; Avery, Mitchell A.; and Williamson, John S., "Microbial Transformation of Artemisinin to 5-hydroxyartemisinin by Eurotium amstelodami and Aspergillus niger" (2006). Office for Research Publications and Presentations. 16.
https://ecommons.udayton.edu/ofr_pub/16