Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease

Author(s)

José C. Barros, Federal University of Rio de Janeiro
Joaquim F. M. da Silva, Federal University of Rio de Janeiro
Alexandre R. Calazans, Federal University of Rio de Janeiro
Amilcar Tanuri, Federal University of Rio de Janeiro
Rodrigo de Morais Brindeiro, Federal University of Rio de Janeiro
John S. Williamson, University of DaytonFollow
Octavio A.C. Antunes, Universidade do Brasil

Document Type

Article

Publication Date

2006

Publication Source

Letters in Organic Chemistry

Abstract

New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.

Inclusive pages

882-886

ISBN/ISSN

1570-1786

Comments

Permission documentation is on file.

Copyright

Copyright © 2006, Bentham Science Publishers

Publisher

Bentham Science Publishers

Volume

3

Issue

12

Peer Reviewed

yes

eCommons Citation

Barros, José C.; da Silva, Joaquim F. M.; Calazans, Alexandre R.; Tanuri, Amilcar; de Morais Brindeiro, Rodrigo; Williamson, John S.; and Antunes, Octavio A.C., "Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease" (2006). Office for Research Publications and Presentations. 41.
https://ecommons.udayton.edu/ofr_pub/41