Pseudo-Peptides Derived from Isomannide as Potential Inhibitors of Serine Proteases
Hepatitis C, dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.
Copyright © 2005, Springer-Verlag/Wien
Muri, Estela M.F.; Gomes, Marlito Jr.; Albuquerque, Magaly Girão; da Cunha, Elaine F. F.; de Alencastro, Ricardo Bicca; Williamson, John S.; and Antunes, Octavio A.C., "Pseudo-Peptides Derived from Isomannide as Potential Inhibitors of Serine Proteases" (2005). Office for Research Publications and Presentations. 1.