Reduced Perylenequinone Derivatives from an Endophytic Alternaria sp. Isolated from Pinus ponderosa

Author(s)

Ahmed Idris, Oregon State University
Mudasir A. Tantry, University of Kashmir
Bashir A. Ganai, University of Kashmir
Azra N. Kamili, University of Kashmir
John S. Williamson, University of DaytonFollow

Document Type

Article

Publication Date

3-2015

Publication Source

Phytochemistry Letters

Abstract

The consecutive solvent extraction of endophytic Alternaria sp. (DC401) isolated from Pinus ponderosa followed by chromatographic techniques led to the isolation of five perylenequinone compounds and one dihydronaphthaquinone derivative, which include three new perylenequinones (1–3). The compounds were identified as 6-methoxy-3,6a,7,10-tetrahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (1), 3,6a,9,10-tetrahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (2), 6-methoxy-3,6a,9,10-tetrahydroxy-7,8-epoxy-4-oxo-4,5,6,6a,6b,7,8,9-octahydroperylene (3), 3,6a,7,10-tetrahydroxy-4,9-dioxo-4,5,6,6a,6b,7,8,9-octahydroperylene (altertoxin I) (4), 3,6a,7,10-tetrahydroxy-4,9-dioxo-4,6a,6b,7,8,9-hexahydroperylene (dehydroaltertoxin I) (5), and 7-chloroscytalone (6). Structure of compounds 1–6 was determined on the basis of detailed spectroscopic analysis, as well as by comparison with literature reports. The antileismanial, antimicrobial, antimalarial and in vitro cytotoxic activities of compounds 1–6 were evaluated.

Inclusive pages

264–269

ISBN/ISSN

1874-3900

Comments

Permission documentation is on file.

Copyright

Copyright © 2015, Phytochemical Society of Europe

Publisher

Elsevier

Volume

11

Peer Reviewed

yes

eCommons Citation

Idris, Ahmed; Tantry, Mudasir A.; Ganai, Bashir A.; Kamili, Azra N.; and Williamson, John S., "Reduced Perylenequinone Derivatives from an Endophytic Alternaria sp. Isolated from Pinus ponderosa" (2015). Office for Research Publications and Presentations. 12.
https://ecommons.udayton.edu/ofr_pub/12