Biotransformation of Artemisinin by Aspergillus niger

Author(s)

Yulian Zhan, Guilin University of Electronic Technology
Hua Liu, University of Mississippi
Yunshan Wu, University of Mississippi
Pingying Wei, Guilin University of Electronic Technology
Zhencheng Chen, Guilin University of Electronic Technology
John S. Williamson, University of DaytonFollow

Document Type

Article

Publication Date

4-2015

Publication Source

Applied Microbiology and Biotechnology

Abstract

Biotransformation of artemisinin (1) by Aspergillus niger was investigated. During 12 days at 28 °C and pH 6.0, A. niger transformed artemisinin into four products. They were identified as 3β-hydroxy-4,12-epoxy-1-deoxyartemisinin (2), artemisinin G (3), 3,13-epoxyartemisinin (4), and 4α-hydroxy-1-deoxyartemisinin (5). Products 2 and 4 are new compounds and are being reported here for the first time. The product 4 contains a 3,13-epoxy structure. This is the first report of epoxidation of artemisinin using microbial strains. The product 4 still has an intact peroxide bridge and therefore can be used as a scaffold for further structural modification using chemical and biological methods in the search for new antimalarial drugs.

Inclusive pages

3443–3446

ISBN/ISSN

0175-7598

Comments

Permission documentation is on file.

Copyright

Copyright © 2015, Springer-Verlag Berlin Heidelberg

Publisher

Springer

Volume

99

Issue

8

Peer Reviewed

yes

eCommons Citation

Zhan, Yulian; Liu, Hua; Wu, Yunshan; Wei, Pingying; Chen, Zhencheng; and Williamson, John S., "Biotransformation of Artemisinin by Aspergillus niger" (2015). Office for Research Publications and Presentations. 24.
https://ecommons.udayton.edu/ofr_pub/24