Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors
Letters in Drug Design & Discovery
A computer-generated homology model of the antimicrobial target Helicobacter pylori urease was derived, using the x-ray crystal structure of Klebsiella aerogenes as a template, in order to design novel urease inhibitors. Based on these computational studies, several heterocyclic hydroxamic acid derivatives have been designed, synthesized, and examined for their ability to inhibit urease activity.
Copyright © 2004, Bentham Science Publishers
Bentham Science Publishers
Muri, Estela M.F.; Mishra, Hetal; Stein, S. M.; and Williamson, John S., "Molecular Modeling, Synthesis And Biological Evaluation of Heterocyclic Hydroxamic Acids Designed as Helicobacter Pylori Urease Inhibitors" (2004). Office for Research Publications and Presentations. 15.