Document Type
Article
Publication Date
2009
Publication Source
Pharmaceutical Biology
Abstract
Microbial transformation of natural products is a well established model for mammalian metabolism. Salvinorin A, a diterpenoid isolated from the hallucinogenic mint Salvia divinorum Epling & Játiva-M (Lamiaceae), is a potent non-nitrogenous κ-opioid receptor agonist. The metabolism of salvinorin A has still not yet been well established. Thirty fungal species were screened for the ability to metabolize salvinorin A. We observed that salvinorin A undergoes fast hydrolysis of the acetate group at carbon atom C2, resulting in formation of the pharmacologically inactive product, salvinorin B. Ex vivo experiments were also performed using organelle fractions isolated from rat liver and brain. Crude tissue homogenate and individual organelles show that the primary route of salvinorin A metabolism is hydrolysis to salvinorin B. No metabolic transformation of salvinorin B was observed in these studies.
Inclusive pages
1078-1084
ISBN/ISSN
1388-0209
Document Version
Published Version
Copyright
Copyright © 2009, Informa UK
Publisher
Taylor & Francis
Volume
47
Issue
11
Peer Reviewed
yes
eCommons Citation
Kutrzeba, Lukasz M.; Karamyan, Vardan T.; Speth, Robert C.; Williamson, John S.; and Zjawiony, Jordan K., "In vitro Studies on Metabolism of Salvinorin A" (2009). Office for Research Publications and Presentations. 31.
https://ecommons.udayton.edu/ofr_pub/31
Included in
Animal Experimentation and Research Commons, Environmental Microbiology and Microbial Ecology Commons, Pharmacology Commons
Comments
This article is provided for download in compliance with the publisher's open access policy. Permission documentation is on file.