A New Method in Organophosphate Synthesis

A New Method in Organophosphate Synthesis

Presenter(s)

Emily Kathryn Granger, Kasia Maria Solomianko

Description

A variety of nucleophilic and Lewis acid catalysts were examined for use in promoting the synthesis of organophosphate triesters. All 8 organophosphate triesters are new compounds, reported here for the first time. MgSO4 was discovered as an inexpensive catalyst capable of improving the synthesis of a variety of aryl organophosphate triesters from the readily available and low cost precursor phosphorus oxychloride in a three-step, two-pot sequence. Yields for this method improve upon the uncatalyzed method by 8-36%. Although several chiral catalysts were tested, none were able to induce enantioselectivity in the reaction.

Publication Date

4-18-2018

Project Designation

Independent Research

Primary Advisor

Jeremy M. Erb

Primary Advisor's Department

Chemistry

Keywords

Stander Symposium project

A New Method in Organophosphate Synthesis

Share

COinS