A New Method in Organophosphate Synthesis

A New Method in Organophosphate Synthesis

    Presenter(s)

    Emily Kathryn Granger, Kasia Maria Solomianko

    Description

    A variety of nucleophilic and Lewis acid catalysts were examined for use in promoting the synthesis of organophosphate triesters. All 8 organophosphate triesters are new compounds, reported here for the first time. MgSO4 was discovered as an inexpensive catalyst capable of improving the synthesis of a variety of aryl organophosphate triesters from the readily available and low cost precursor phosphorus oxychloride in a three-step, two-pot sequence. Yields for this method improve upon the uncatalyzed method by 8-36%. Although several chiral catalysts were tested, none were able to induce enantioselectivity in the reaction.

    Publication Date

    4-18-2018

    Project Designation

    Independent Research

    Primary Advisor

    Jeremy M. Erb

    Primary Advisor's Department

    Chemistry

    Keywords

    Stander Symposium project

    A New Method in Organophosphate Synthesis

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