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Virtual Yoga Instructor
Nikesh Chithambaram
Engaging in high-impact physical activities may not be suitable for senior adults due to their age and traditional exerciseprograms may not always be accessible or motivating. Adaptive yoga provides a range of low-effort exercises tailored to different age groups as well as individuals with disabilities that can improve both physical and mental fitness. However, post-pandemic travel can make attending yoga sessions challenging. To address this, we propose an augmented-reality application that encourages seniors to learn and practice yoga in an immersive mixed-reality environment in a surrounding of their comfort while promoting an active lifestyle and healthy aging.The proposed yoga application uses a database of yoga poses to provide guidance and feedback to users. It has a virtual instructor to guide the user and allows them to interact with both virtual and real-world elements with the help of a mixed-reality headset. During each workout session, the application will provide live feedback with the help of a camera to correct and validate yoga poses. The application allows the user to workout with friends represented by virtual avatars in a joint yoga session.Yoga provides numerous health benefits including strengthened bones, enhanced balance and flexibility which decreases the risk of falls and improve overall physical fitness. Practicing yoga regularly can lead to improved quality of sleep, promote mental fitness and clarity for the elderly. By providing live feedback, the application ensures the exercises are practiced safe. The user can use a mixed reality headset in the comfort of their home or preferred location, without the need to travel to a yoga studio. This provides a safer solution and also promotes independence for senior adults. Working out together with friends or family represented by virtual avatars can also help promote a sense of community and belonging, enhancing overall mental health and well-being.
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Visual CAPTCHA Resilience Evaluation
Rohan Ravindra Patil, Saumya Hiten Shah
Visual CAPTCHAs are widely used to prevent automated bots from accessing online services. However, their effectiveness heavily relies on their resilience against automated attacks while maintaining user accessibility. The CAPTCHA resilience represents the ability of the trained models to detect the object during the adversarial attack. By evaluating the performance of the noise injected CAPTCHAs, our study aims to contribute to the ongoing efforts in developing more resilient and robust CAPTCHA systems.
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Whose Voices Matter?
Caroline Anne Cochran
This THR/VAR 250 Diversity in the Creative and Performing Arts poster presentation project requires each student to research and present on a topic relevant to the interdisciplinary fields of visual and performing arts through a critical multicultural and social justice lens that foregrounds the appreciation of diversity and enables the expansion of personal cultural competencies.
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Wildlife activity patterns vs human recreation in Five River Metroparks
Elizabeth Ann Divish
Fiver River Metroparks, along the Miami River watershed in Ohio is home to many species of animals and public hiking trails. The public parks in Germantown, Upper Twin Creek and Twin Creek have many chances to interact with the biodiversity while participating in outdoor recreation. The park data has been documented, organized and analyzed to determine the possible impacts that hiking trails and recreation have on wildlife activity throughout the day. This data was collected through the months of September, October and November, 2023, using camera traps to identify the time the individuals were active and the behavior they were exhibiting. Some of the species identified include: Raccoon (Procyon lotor), White-Tailed Deer(Odocoileus virginianus), Coyote (Canis latrans), and Squirrels (Sciurus sp). Through the research the relationship between human temporal recreational activity and the activity of animals at these locations has been compared. This will determine if the construction and implementation of new trails at any of these locations would be beneficial or detrimental to the current biodiversity inhabiting the parks.
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Young Drivers Texting and Driving Behaviors
Kyle Douglas Hazell, Emily Noelle Parker
This research project explores the relationship between texting tendencies and mobility in everyday life among two age groups: young drivers (aged 17-22) and middle-aged drivers (aged 23-35). It is relevant because it directly involves drivers of all ages, as distracted drivers can pose a danger to drivers and non-drivers. It is also important because it allows us to study distracted driving indicators, and explore strategies to mitigate them. Through our secondary data analysis, we found there is a very strong correlation between phone use and distracted driving. The results indicated no significant difference between the two age groups when the involvement in distracted driving incidents was compared. Furthermore, this research analyzes the correlation between the occurrence of distracted driving incidents and the drivers’ age among both cohorts. Finally, the research hopes to explore the dynamic between “texting communication while driving” and engagement in other distracted driving behaviors.
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ZFP36L1 suppresses Rotavirus and Norovirus replication, moderates the virus-induced hyperinflammation and suppresses host cell damage.
Malabika Bhowmik, Tooba Shafeeque Ahmed Momin
Title: ZFP36L1 suppresses Rotavirus and Norovirus replication, moderates the virus-induced hyperinflammation and suppresses host cell damage.Malabika Bhowmik, Tooba MominPrimary Advisor: Mrigendra RajputDepartment of Biology, University of Dayton, Dayton, Ohio, USA 45469 Most acute viral infections cause damage in the host body either directly when the virus hijacks the host cell machinery, changes cell physiology, causes cell death by viral proteins, or indirectly by hyperinflammation. Zinc finger proteins (ZFP) are one of the highly abundant proteins in eukaryotes. Due to their distinctive structure, ZFPs bind with different cellular components such as DNA, RNA, lipids, or other proteins. A specific type of ZFP, ZFP36L1, belongs to the CCCH-type ZFP, which has been identified as a regulator of RNA metabolism. It is known to control the overall turnover of cellular mRNA including mRNA of cytokine mediators and cytokines by breaking it down through poly A tail using the deadenylation mechanism. The current study was designed to investigate the role of ZFP36L1 on virus replication and moderating virus-induced inflammation. Our results showed that stable overexpression of ZFP36L1 through lentivirus transduction significantly reduces Rotavirus and Norovirus titre as well as it moderated virus-induced proinflammatory cytokines like IFN-α and TNF-α with reduced virus-induced cytopathic effect in cells. While knockdown of ZFP36L1 significantly enhanced viral titre, virus-induced cytokines with more cytopathic effect. Our results also showed that ZFP36L1 overexpression does not affect macrophage (RAW 264.7) migration as compared to control while knockdown of ZFP36L1 significantly enhanced the macrophage migration in trans-wells. Overall, our study showed that overexpression of ZFP36L1 suppresses the virus (Rotavirus and Norovirus) replication and moderates the virus-induced hyperinflammation and thus mitigates virus-induced damage in the host.
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ZFP36L1 Suppresses Virus Replication Independent of Poly(A) Tail Deadenylation
Malabika Bhowmik, Tooba Shafeeque Ahmed Momin, Abiageal Rai Newell
ZFP36L1, a CCCH-type zinc figure protein (ZFP) is recognized for its involvement in RNA stability and its decay via poly A tail deadenylation [removal of the poly(A) tail from mRNA]. This ability allows ZFP36L1 to exhibit antiviral activity against a variety of viruses, including flaviviruses, retroviruses, and alphaviruses. Our preliminary investigation demonstrated the antiviral role of ZFP36L1 against the human coronavirus OC43 (HCoV-OC43) and murine norovirus 1 (MNV1). The overexpression of ZFP36L1 reduced the HCoV-OC43 production, whereas its knockdown significantly enhanced the virus production. We aimed to understand how ZFP36L1 influences viral replication. To gain further insight into the role of poly-A tail deadenylation in the suppression of HCoV-OC43 by ZFP36L1, we knocked down CNOT1, a key regulator of mRNA decay, in ZFP36L1 overexpressed cells. Results showed that the virus titer reduction was not rescued in CNOT1 knockdown cells compared to the overexpressed ZFP36L1 cells. These results indicated that the reduction in HCoV-OC43 replication was independent of poly-A tail deadenylation.We further employed computational analysis, utilizing RNA-protein interaction prediction software and docking simulations, which indicated a significant interaction between ZFP36L1 and the viral nucleocapsid. Further investigations into ZFP36L1's effect on nucleocapsid expression revealed that ZFP36L1 overexpression led to a decrease in nucleocapsid expression suggesting a direct interaction between ZFP36L1 and viral components that may underlie its antiviral activity. We have also performed RNA immunoprecipitation experiments which have shown the interaction between ZFP36L1 and the nucleocapsid. This interaction will further be validated using luciferase assays. Overall, our study showed an additional pathway by which ZFP36L1 suppresses the virus replication.
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